Buffer solution preparation is one of the most resource-intensive activities in biopharmaceuticals, and the preparation and storage of large quantities of buffer solutions is time-consuming and space-consuming, becoming a major bottleneck in the manufacturing process. After the online liquid preparation system equipment is used in the pharmaceutical process, the number and space of storage tanks are saved, and the daily maintenance cost is reduced. It is one of the best solutions for solution preparation automation.

    The online liquid preparation system equipment mixes high-concentration, low-volume, single-component solutions (acid, alkali, salt, WFI, etc.) online to prepare the required buffer solution. The liquid preparation process is controlled by a series of sensors, including flow meters after each pump, as well as pH and conductivity sensors after the mixing point. The system includes three feedback control modes: (1) recipe and flow feedback control mode; (2) pH and conductivity feedback control mode; (3) pH value and flow feedback control mode. The PLC control system monitors the pH value and conductivity of the mixed buffer in real time. If the detected value exceeds the set limit, the system will automatically discharge the unqualified solution. Ensures that only the correct buffer reaches the collection vessel, thereby creating a robust and reliable production process.